Depop's 'Depopamine': Key Findings
- Depop’s new OOH and social ads spotlight the emotional high shoppers feel when finding secondhand fashion gems.
- Titled “Depopamine,” the campaign uses close-ups of eyes, mouths, and goosebumps to capture that discovery moment.
- Murals and targeted city placements tie into Depop’s wider advertising strategy to make circular fashion more desirable.
Quick listen: How Depop branded the thrill of secondhand fashion — in under 2 minutes.
When Depop users stumble upon the perfect vintage jacket or retro tee, the rush can feel unforgettable.
Now, the secondhand fashion marketplace is putting that sensation front and center in its new campaign with Uncommon Creative Studio.
Titled “Depopamine,” the work recreates the physical and emotional high shoppers feel when they find exactly what they’ve been searching for.

The OOH and social ads feature extreme close-ups of wide eyes, gaping mouths, and raised arm hairs, all paired with the tagline “Found It on Depop.”
“Depopamine puts a name to the moment of discovery that comes with finding something special — showing just how exciting, creative and individual secondhand fashion can be," Sonia Biddle, Depop’s chief product officer, shared.
“Our mission is to make fashion circular, and the key to this is making secondhand fashion the most inspiring and desirable alternative to new."
The campaign marks the first work between Depop and Uncommon, showing how ready the brand is to stand out in a resale market against big players like eBay and Vinted.
It’s a move that speaks directly to the marketplace’s Gen Z and millennial user base, where individual style and sustainability are valued traits that often go hand in hand.
Murals, City Takeovers, and More
The “Depopamine” rollout spans billboards, posters, and digital screens in key UK markets, including Manchester and Liverpool.
In a standout activation, Depop commissioned a mural on the shutters of Noho bar in Manchester’s Northern Quarter, painted by Global Street Art.
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The decision to go hyper-local with placements aligns with Depop’s push to make secondhand fashion not only accessible but also aspirational.
Visuals that mimic the neurological “hit” of a good find are a sidestep the campaign took from traditional fashion advertising, favoring something more visceral and immediate instead.
While OOH dominates the launch, Depop is also extending the creative to social media platforms, ensuring the concept lives where its audience spends most of its time.
Overall, the street-level art, shareable visuals, and catchy campaign name give “Depopamine” many likable attributes that can easily resonate with users both online and offline.
Our Take: Can You Sell The 'High'?
I think Depop is smart to lean into the emotional side of shopping.
Plenty of resale platforms can claim sustainability or variety, but few can brand a physical reaction.
What stands out is how well the concept works across both street murals and social feeds, making it easy to engage with regardless of medium.
The lesson here? Selling the feeling behind your product can sometimes be just as effective as selling the product itself.
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